The Owls had good periods in the clash but were ultimately overpowered by an Ivan Toney-inspired Bees side.
Alex Miller has put together his player ratings – what do you think?
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1. Cameron Dawson - 5
One mistake cost him - he'd have wanted to deal with the first better as his parry allowed Brentford to break back in. The first wobble in an otherwise excellent start to the season. Communicated very well on an evening that was needed. Photo: Steve Ellis
2. Moses Odubajo - 5
You feel for Odubajo. He's playing out of position but his failure to mark Ivan Toney for the second killed Wednesday's momentum. Out of position once or twice - will want to get back to wing-back ASAP to continue his good work out wide. Photo: Steve Ellis
3. Aden Flint - 6
The best of a back three that was torn to bits at points, Flint did his best to organise and made some important clearances. Long ball a little over-utilised you feel. Photo: Tony Marshall
4. Joost van Aken - 6
Looked a little sluggish in the face of a rapid Brentford attack. Headed well but was turned once or twice. Had his work cut out. Another who will be keen to get back at it on Saturday. Photo: Steve Ellis