A tough 2020/21 campaign has seen the Blades rooted to the foot of the table for much of the season, and despite recent claims from the club’s owners that they were hopeful of keeping hold of Wilder regardless of what division United are in next season, it would appear that their slump has ultimately led to the manager's departure.
U23s manager Paul Heckingbottom looks set to take the job on a caretaker basis while the Blades find the right man to take the club forward in the long-term.
Here's our rundown of the SkyBet's current front-runners for the job, ranked from the worst to best chance of becoming Sheffield United' s next permanent boss:
1. Garry Monk - Current odds: 25/1
Current job: Unemployed. Last club: Sheffield Wednesday. Career win percentage: 38.4% (Photo by Alex Livesey/Getty Images) Photo: Alex Livesey
2. Derek McInnes - Current odds: 22/1
Current job: Unemployed. Last club: Aberdeen. Career win percentage: 47.4% (Photo by Ian MacNicol/Getty Images) Photo: Ian MacNicol
3. Paul Warne - Current odds: 20/1
Current job: Rotherham United. Career win percentage: 34.2% (Photo by Charlotte Tattersall/Getty Images) Photo: Charlotte Tattersall
4. Mark Hughes - Current odds: 20/1
Current job: Unemployed. Last job: Southampton. Career win percentage: 37.7% (Photo by Dan Istitene/Getty Images) Photo: Dan Istitene