The latest data, which covers the seven days to 2 October, shows 30 or more cases were recorded in nine areas of the city, with a further two neighbourhoods recording 29 cases.
There were 320 cases per 100,000 people in the seven days to 3 October. The average area in England had 55.
Here are the most infectious places. Images are for illustrative purposes only and are not linked to the data in the article.
1. Shoppers wearing masks as they return to the shops in Sheffield City Centre
Shoppers wearing masks in Sheffield city centre. Photo: DEAN ATKINS
2. Broomhill and Lower Crookesmoor
49 cases recorded between 26 September and 3 October. Photo: Steve Ellis
3. Upperthorpe, Netherthorpe and Langsett
39 cases recorded between 26 September and 2 October. Photo: DEAN ATKINS
4. Burngreave and Grimesthorpe
33 cases recorded from 26 September to 2 October. Photo: Scott Merrylees